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Mouse CD3z (CD247) monoclonal antibody (FITC) (AGIM0254)

SKU:
AGIM0254
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Hamster
Isotype:
IgG2??
Clone:
H146-968
Conjugation:
FITC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:Mouse CD3z (CD247) monoclonal antibody (FITC)
Product Code:AGIM0254
Size:500 µL
Reactivity:Mouse
Clone:H146-968
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG2??
Host Species:Hamster
Storage:Stable at 4°C. Avoid prolonged exposure to light.
Uniprot:P20963
UniProt Protein Function:CD3Z: a T cell surface glycoprotein that is a component of the T cell antigen receptor. Plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the CD3-epsilon results in impaired immune response. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex

Molecular Function:identical protein binding; protein binding; protein homodimerization activity; transmembrane receptor activity

Biological Process: regulation of immune response; viral reproduction; T cell costimulation; innate immune response; T cell receptor signaling pathway; regulation of defense response to virus by virus

Disease: Immunodeficiency 25

NCBI Summary:The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P20963
NCBI GenInfo Identifier:4557431
NCBI Gene ID:919
NCBI Accession:NP_000725.1
UniProt Secondary Accession:P20963,Q5VX13, Q8TAX4, B1AK49,
UniProt Related Accession:P20963,A46461
Molecular Weight:18,696 Da
NCBI Full Name:T-cell surface glycoprotein CD3 zeta chain isoform 2
NCBI Synonym Full Names:CD247 molecule
NCBI Official Symbol:CD247  
NCBI Official Synonym Symbols:T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA  
NCBI Protein Information:T-cell surface glycoprotein CD3 zeta chain; CD3zeta chain; TCR zeta chain; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, zeta polypeptide (TiT3 complex); T-cell antigen receptor complex, zeta subunit of CD3
UniProt Protein Name:T-cell surface glycoprotein CD3 zeta chain
UniProt Synonym Protein Names:T-cell receptor T3 zeta chain
UniProt Gene Name:CD247  
UniProt Entry Name:CD3Z_HUMAN

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