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PE Anti-Mouse CD366/Tim-3 Antibody [RMT3-23] (AGEL2007)

SKU:
AGEL2007
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€159 - €389
Frequently bought together:

Description

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PE Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]

The Mouse CD366 (TIM-3) Monoclonal Antibody (PE Conjugated) (RMT3-23) is a cutting-edge tool for researchers focusing on the immune checkpoint molecule TIM-3. This monoclonal antibody specifically targets the TIM-3 protein, a crucial regulator of immune responses and tolerance. With its PE conjugation, this antibody allows for precise and sensitive detection of TIM-3 in various research applications.TIM-3, a member of the T-cell immunoglobulin and mucin domain (TIM) family, is known for its role in regulating T cell exhaustion and immune tolerance. Studies have highlighted its involvement in immune evasion by tumor cells and its potential as a target for cancer immunotherapy.

By utilizing the RMT3-23 antibody, researchers can delve deeper into the mechanisms underlying TIM-3-mediated immune regulation and explore novel therapeutic strategies in immuno-oncology and autoimmune diseases.This advanced antibody offers researchers a reliable tool for investigating TIM-3 function in diverse biological contexts, including immunology, oncology, and autoimmunity. By enhancing our understanding of TIM-3 biology, this antibody contributes to the development of innovative treatments aimed at modulating immune responses and improving clinical outcomes in diseases where TIM-3 plays a pivotal role.

Product Title:PE Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]
SKU:AGEL2007
Size:25µg, 100µg
Clone No:RMT3-23
Synonyms:TIM3; TIMD3;HAVcr-2;TIMD-3;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q8VIM0
Gene ID:84868
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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