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APC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23] (AGEL2008)

SKU:
AGEL2008
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€179 - €459
Frequently bought together:

Description

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APC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]

The Mouse CD366 (Tim-3) Monoclonal Antibody, APC Conjugated (RMT3-23) is a vital tool for immunological research, particularly in the study of Tim-3, a cell surface receptor associated with immune regulation and exhaustion. This monoclonal antibody, specifically engineered for mouse samples, is conjugated with APC for easy detection and analysis in flow cytometry and immunofluorescence applications. By targeting the Tim-3 protein, this antibody allows precise identification and characterization of immune cells expressing Tim-3, facilitating investigations into immune responses, tolerance, and immunotherapy.Tim-3, a member of the T-cell immunoglobulin and mucin domain-containing protein family, serves as a crucial checkpoint molecule in immune responses by modulating T-cell function and tolerance.

Its role in regulating immune tolerance and exhaustion has significant implications for understanding chronic infections, autoimmune diseases, and cancer. The ability to accurately detect and measure Tim-3 expression using the APC-conjugated RMT3-23 antibody enables researchers to delve deeper into the mechanisms underlying immune dysfunction and develop novel therapeutic strategies targeting Tim-3 for various immune-related disorders.

Product Title:APC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]
SKU:AGEL2008
Size:25µg, 100µg
Clone No:RMT3-23
Synonyms:TIM3; TIMD3;HAVcr-2;TIMD-3;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q8VIM0
Gene ID:84868
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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