Mouse CD36 Recombinant Protein (RPPB3069)
- SKU:
- RPPB3069
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- Q08857
- Research Area:
- CD Antigens
Description
| Product Name: | Mouse CD36 Recombinant Protein |
| Product Code: | RPPB3069 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | CD36 |
| Synonyms: | Platelet glycoprotein 4, Glycoprotein IIIb, GPIIIB, PAS IV, PAS-4, Platelet glycoprotein IV, GPIV, CD36, Cd36. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterilefiltered colorless solution. |
| Formulation: | CD36 protein solution (1mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPGDMLIEK TIKREVVLEE GTTAFKNWVK TGTTVYRQFW IFDVQNPDDVAKNSSKIKVK QRGPYTYRVR YLAKENITQD PEDHTVSFVQ PNGAIFEPSL SVGTEDDNFT VLNLAVAAAPHIYQNSFVQV VLNSLIKKSK SSMFQTRSLK ELLWGYKDPF LSLVPYPIST TVGVFYPYND TVDGVYKVFNGKDNISKVAI IESYKGKRNL SYWPSYCDMI NGTDAASFPP FVEKSRTLRF FSSDICRSIY AVFGSEIDLKGIPVYRFVLP ANAFASPLQN PDNHCFCTEK VISNNCTSYG VLDIGKCKEG KPVYISLPHF LHASPDVSEPIEGLHPNEDE HRTYLDVEPI TGFTLQFAKR LQVNILVKPA RKIEALKNLK RPYIVPILWL NETGTIGDEKAEMFKTQVTG KIKHHHHHH |
Plateletglycoprotein IV, also known as CD36 is an integral membrane glycoprotein whichhas multiple physiological functions. CD36 is broadly expressed on a wide arrayof cell types. CD36 is part of the scavenger receptor family and acts as amultiligand pattern recognition receptor which interacts with a large number ofstructurally dissimilar ligands. Furthermore, CD36 participates in lipidmetabolism and has been known as a fatty acid translocase which is required forthe bindingas well as transport of LCFA in cells & tissues. CD36 also takes a major partin the initiation as well as pathogenesis of chronic inflammatory diseases suchas Alzheimer�s disease and atherosclerosis. CD36 is an integral membraneprotein which mainly functions as a receptor for thrombospondin & collagen.CD36 directly mediates the cytoadherence of Plasmodium falciparum parasitizederythrocytes.
CD36 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 419 amino acids (30-439a.a.) and having a molecular mass of 47.4kDa (Molecular size on SDS-PAGE will appear at approximately 57-70kDa).CD36 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Cell adhesion Cellular Component: Golgi apparatus; extracellular space; protein complex; cell surface; mitochondrion; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane; caveola; lipid raft; membrane; apical part of cell; plasma membrane; intracellular; sarcolemma; external side of plasma membrane Molecular Function:low-density lipoprotein receptor activity; protein binding; transforming growth factor beta binding; low-density lipoprotein binding; high-density lipoprotein binding; lipid binding Biological Process: positive regulation of blood coagulation; positive regulation of interleukin-12 production; cGMP-mediated signaling; phagocytosis, recognition; pattern recognition receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; signal transduction; fatty acid metabolic process; negative regulation of transcription factor import into nucleus; low density lipoprotein mediated signaling; sequestering of lipid; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; transport; positive regulation of cell-matrix adhesion; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; cell adhesion; long-chain fatty acid transport; receptor-mediated endocytosis; cholesterol transport; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of systemic arterial blood pressure; positive regulation of interleukin-6 production; long-chain fatty acid metabolic process; positive regulation of tumor necrosis factor production; negative regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; triacylglycerol metabolic process; response to mechanical stimulus; lipoprotein transport; fatty acid oxidation; positive regulation of phagocytosis, engulfment; plasma membrane long-chain fatty acid transport; nitric oxide mediated signal transduction; apoptotic cell clearance; fatty acid transport; positive regulation of cytokine secretion |
| UniProt Code: | Q08857 |
| NCBI GenInfo Identifier: | 729081 |
| NCBI Gene ID: | 12491 |
| NCBI Accession: | Q08857.2 |
| UniProt Related Accession: | Q08857 |
| Molecular Weight: | 52,698 Da |
| NCBI Full Name: | Platelet glycoprotein 4 |
| NCBI Synonym Full Names: | CD36 antigen |
| NCBI Official Symbol: | Cd36�� |
| NCBI Official Synonym Symbols: | FAT; GPIV; Scarb3�� |
| NCBI Protein Information: | platelet glycoprotein 4; PAS-4; GPIIIB; PAS IV; glycoprotein IIIb; fatty acid translocase; platelet glycoprotein IV |
| UniProt Protein Name: | Platelet glycoprotein 4 |
| UniProt Synonym Protein Names: | Glycoprotein IIIb; GPIIIB; PAS IV; PAS-4; Platelet glycoprotein IV; GPIV; CD_antigen: CD36 |
| Protein Family: | Platelet glycoprotein |
| UniProt Gene Name: | Cd36�� |
| UniProt Entry Name: | CD36_MOUSE |
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