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Mouse CD3 monoclonal antibody (AGIM0256)

SKU:
AGIM0256
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Hamster
Isotype:
IgG1, k
Clone:
DaA3
Conjugation:
Unconjugated
Applications:
FC
€179
Frequently bought together:

Description

system_update_altDatasheet
Product Name:Mouse CD3 monoclonal antibody
Product Code:AGIM0256
Size:100 µg in 100 µL
Reactivity:Mouse
Clone:DaA3
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1, k
Host Species:Hamster
Storage:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:P04234
UniProt Protein Function:CD3D: a T cell surface glycoprotein that is a component of the T cell antigen receptor. A defect in this protein causes a severe combined immunodeficiency characterized by the absence of T cells but normal B cells. Contains 1 ITAM domain.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; cytoplasm; plasma membrane; integral to membrane; alpha-beta T cell receptor complex

Molecular Function:transmembrane receptor activity; protein heterodimerization activity; transcription coactivator activity

Biological Process: regulation of immune response; cell surface receptor linked signal transduction; T cell costimulation; positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; T cell differentiation; positive thymic T cell selection

Disease: Immunodeficiency 19

NCBI Summary:The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]
UniProt Code:P04234
NCBI GenInfo Identifier:115985
NCBI Gene ID:915
NCBI Accession:P04234.1
UniProt Secondary Accession:P04234,A8MVP6,
UniProt Related Accession:P04234
Molecular Weight:171
NCBI Full Name:T-cell surface glycoprotein CD3 delta chain
NCBI Synonym Full Names:CD3d molecule, delta (CD3-TCR complex)
NCBI Official Symbol:CD3D  
NCBI Official Synonym Symbols:T3D; IMD19; CD3-DELTA  
NCBI Protein Information:T-cell surface glycoprotein CD3 delta chain; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex)
UniProt Protein Name:T-cell surface glycoprotein CD3 delta chain
UniProt Synonym Protein Names:T-cell receptor T3 delta chain; CD_antigen: CD3d
Protein Family:CD302 antigen
UniProt Gene Name:CD3D  
UniProt Entry Name:CD3D_HUMAN

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