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PE Anti-Mouse CD28 Antibody [37.51] (AGEL0767)

Datasheet MSDS
SKU AGEL0767
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Hamster
Isotype IgG2a,k
Clone 37.51
Conjugation PE
€63 - €203

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Description

system_update_altDatasheetsystem_update_altMSDS

PE Anti-Mouse CD28 Antibody [37.51]

The Mouse CD28 Monoclonal Antibody PE Conjugated (37-51) is a specialized antibody designed for research purposes involving CD28, a crucial cell surface receptor involved in T-cell activation and immune response modulation. This monoclonal antibody, conjugated with PE (phycoerythrin), is specifically targeted towards mouse samples and is optimized for flow cytometry applications. By binding to the CD28 protein, this antibody allows for precise detection and analysis of CD28 expression in various cell types, making it an essential tool for immunology and immunotherapy research.CD28 is a co-stimulatory molecule that plays a pivotal role in T-cell activation and the regulation of immune responses. It is a key player in the activation and proliferation of T-cells, making it a valuable target for studies related to autoimmune diseases, cancer immunotherapy, infectious diseases, and transplant rejection.

Understanding the mechanisms by which CD28 functions in T-cell activation is essential for developing targeted therapeutics and immunomodulatory strategies for a range of medical conditions.The Mouse CD28 Monoclonal Antibody PE Conjugated (37-51) offers high specificity and sensitivity in detecting CD28 expression, allowing researchers to gain insights into the role of CD28 in various immunological contexts. With its superior performance in flow cytometry, this antibody is a valuable asset for scientists looking to explore the complexities of immune system regulation and T-cell activation pathways.

Product Title:PE Anti-Mouse CD28 Antibody [37.51]
SKU:AGEL0767
Size:25µg, 100µg
Clone No:37.51
Synonyms:T-cell-specific surface glycoprotein CD28;Cd28;CD28;
Host Species:Syrian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Syrian Hamster IgG
Isotype Control:PE Syrian Hamster IgG Isotype Control[SHG-1]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P31041
Gene ID:12487
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD28 is a 44 kD glycoprotein, also known as Tp44 or T44. It is a member of the Ig superfamily, expressed on thymocytes, most peripheral T cells, and NK cells. In association with CD80 (B7-1) and CD86 (B7-2), CD28 acts as the second signal for T and NK cell activation and proliferation. The 37.51 antibody has been reported to augment in vitro T cell proliferation and cytokine production, and promote CTL development.
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