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PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1635)

SKU:
AGEL1635
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
29F.1A12
Conjugation:
PE/Cy5.5
€219 - €539
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody PE/Cyanine5.5 Conjugated (29F.1A12) is a vital tool for researchers studying immune checkpoints and T cell regulation. This antibody specifically targets the CD279 (PD-1) protein, a key immune checkpoint receptor that plays a crucial role in regulating T cell activation and tolerance.CD279 (PD-1) is known for its role in maintaining immune tolerance by inhibiting T cell activation when bound to its ligands. Dysregulation of the PD-1 pathway has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. This makes the Mouse CD279 (PD-1) Monoclonal Antibody a valuable resource for investigating the mechanisms underlying these conditions and exploring potential therapeutic interventions.

With its PE/Cyanine5.5 conjugation, this antibody allows for sensitive and specific detection of CD279 (PD-1) in flow cytometry applications. Its high reactivity with mouse samples ensures reliable results for studies focusing on immune regulation and T cell function. Researchers in immunology, oncology, and infectious diseases will find this antibody instrumental in their investigations into immune checkpoint pathways and potential immunotherapy strategies.

Product Title:PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1635
Size:25µg, 100µg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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