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PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1630)

SKU:
AGEL1630
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
29F.1A12
Conjugation:
PE/Cy5.5
€169 - €409
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody PE-Cyanine5.5 Conjugated (29F.1A12) from Assay Genie (AGEL1630) is an essential tool for researchers studying immune checkpoint proteins. PD-1, programmed cell death protein 1, is a key regulator of the immune system, known for its role in maintaining self-tolerance and preventing autoimmunity.This monoclonal antibody is specifically designed for flow cytometry applications, offering high sensitivity and specificity for detecting mouse PD-1 expression on immune cells. The PE-Cyanine5.5 conjugation provides bright fluorescence signals with minimal background noise, ensuring accurate and reliable results.By targeting PD-1, researchers can gain insights into immune responses, tolerance mechanisms, and immune evasion strategies employed by cancer cells.

This antibody enables precise identification and quantification of PD-1-positive cells, facilitating detailed analysis of immune checkpoint pathways in various experimental settings.With its validated performance and specificity, the Mouse CD279 (PD-1) Monoclonal Antibody PE-Cyanine5.5 Conjugated (29F.1A12) is a valuable asset for studies focusing on immune regulation, cancer immunotherapy, and immunological disorders. Researchers can leverage this antibody to deepen their understanding of PD-1 biology and explore novel therapeutic interventions targeting immune checkpoints.

Product Title:PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1630
Size:50 Tests, 100 Tests, 200 Tests
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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