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PE Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1628)

SKU:
AGEL1628
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
29F.1A12
Conjugation:
PE
€129 - €299
Frequently bought together:

Description

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PE Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody (PE Conjugated) 29F.1A12 (AGEL1628) is a cutting-edge tool for researchers delving into immune checkpoint pathways. This antibody, specifically designed for detecting the CD279 (PD-1) protein in mouse samples, offers high specificity and sensitivity, making it a reliable choice for flow cytometry applications. By binding to CD279 (PD-1), this antibody allows for precise identification and analysis of immune cells expressing this critical immune checkpoint marker.CD279 (PD-1) is a key immune checkpoint receptor that plays a crucial role in maintaining immune tolerance and preventing autoimmunity. Its dysregulation has been implicated in various diseases, particularly cancer, where it enables tumor cells to evade immune surveillance.

Research on CD279 (PD-1) is instrumental in developing novel immunotherapies that target this pathway to enhance anti-tumor immune responses.The Mouse CD279 (PD-1) Monoclonal Antibody (PE Conjugated) 29F.1A12 (AGEL1628) provides a valuable tool for investigating the role of CD279 (PD-1) in immune regulation and disease pathogenesis. Its application in flow cytometry assays offers researchers the ability to characterize immune cell populations and study the impact of CD279 (PD-1) signaling in various experimental settings. Unlock the potential of immune checkpoint modulation with this specialized antibody designed to advance immunology and cancer research.

Product Title:PE Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1628
Size:50 Tests, 100 Tests, 200 Tests
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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