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FITC Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1627)

SKU:
AGEL1627
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€129 - €299
Frequently bought together:

Description

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FITC Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody (FITC Conjugated, 29F.1A12) is a cutting-edge tool in immunology research. PD-1, also known as Programmed cell Death protein 1, is a key immune checkpoint receptor that plays a crucial role in regulating immune responses. This monoclonal antibody, conjugated with FITC for fluorescent detection, is designed for detecting and analyzing PD-1 in various cell types.PD-1 is a critical mediator of immune tolerance and is involved in regulating T cell activation and immune surveillance mechanisms. The Mouse CD279 (PD-1) Monoclonal Antibody (FITC Conjugated, 29F.1A12) allows for precise detection and measurement of PD-1 expression levels, enabling researchers to study its impact on immune function and its potential role in diseases such as cancer, infectious diseases, and autoimmune disorders.

With its high specificity and sensitivity, this antibody is an invaluable tool for researchers looking to explore the complex interactions of the immune system and develop novel strategies for immunotherapy. Whether investigating immune checkpoint blockade mechanisms or studying immune evasion strategies employed by pathogens, the Mouse CD279 (PD-1) Monoclonal Antibody (FITC Conjugated, 29F.1A12) provides the necessary precision and reliability for advancing immunology research.

Product Title:FITC Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1627
Size:50 Tests, 100 Tests, 200 Tests
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:FITC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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