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Biotin Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL1626)

SKU:
AGEL1626
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€149 - €219
Frequently bought together:

Description

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Biotin Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The Mouse CD279 (PD-1) Monoclonal Antibody Biotin Conjugated (29F.1A12) is a powerful tool for research involving PD-1, a key immune checkpoint protein that plays a crucial role in regulating T cell function. This monoclonal antibody, derived from hybridoma cell culture, specifically targets the PD-1 receptor and is conjugated with biotin for enhanced detection in cellular and molecular biology assays.PD-1, also known as programmed cell death protein 1, is a critical regulator of immune responses, helping to prevent autoimmune reactions and maintain immune tolerance. By interacting with its ligands, PD-L1 and PD-L2, PD-1 inhibits T cell activation and dampens immune responses, making it a promising target for immunotherapy research. The 29F.1A12 antibody enables precise detection and analysis of PD-1 expression in various experimental settings, including flow cytometry, immunohistochemistry, and functional studies.

Research on PD-1 has significant implications for understanding immune evasion mechanisms in cancer, infectious diseases, and autoimmunity. Targeting the PD-1 pathway with therapeutic antibodies has revolutionized cancer treatment, leading to the development of immune checkpoint inhibitors that enhance anti-tumor immune responses. The Mouse CD279 (PD-1) Monoclonal Antibody Biotin Conjugated (29F.1A12) is a valuable asset for investigations into immune checkpoint biology, offering researchers a reliable tool for probing the functions and interactions of PD-1 in diverse immunological contexts.

Product Title:Biotin Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL1626
Size:25µg, 100µg
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Biotin Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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