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Biotin Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL1638)

SKU:
AGEL1638
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€99 - €179
Frequently bought together:

Description

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Biotin Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The Mouse CD274 (PD-L1) Monoclonal Antibody (Biotin Conjugated) 10F.9G2 (AGEL1638) is a powerful tool for researchers studying immune checkpoint protein PD-L1 in mouse samples. This monoclonal antibody, produced for detecting PD-L1 in various cell types, is highly specific and validated for use in applications such as flow cytometry and immunohistochemistry.PD-L1, a key immune checkpoint molecule, plays a crucial role in regulating immune responses by interacting with its receptor PD-1 to suppress T cell activation and prevent immune-mediated tissue damage. The expression of PD-L1 is often dysregulated in various diseases, including cancer, making it an important target for immunotherapy research.

By utilizing the Mouse CD274 (PD-L1) Monoclonal Antibody (Biotin Conjugated) 10F.9G2 (AGEL1638), researchers can effectively study the expression and function of PD-L1 in mouse models, contributing to a deeper understanding of immune evasion mechanisms in cancer and autoimmune diseases. This antibody enables accurate detection and analysis of PD-L1 levels, facilitating valuable insights into immune regulation and potential therapeutic targets.

Product Title:Biotin Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
SKU:AGEL1638
Size:25µg, 100µg
Clone No:10F.9G2
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Biotin Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q9EP73
Gene ID:60533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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