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APC Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL1640)

SKU:
AGEL1640
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
10F.9G2
Conjugation:
APC
€149 - €339
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Description

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APC Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The Mouse CD274 (PD-L1) Monoclonal Antibody (APC Conjugated) 10F.9G2 (AGEL1640) is a powerful tool for researchers studying immune checkpoint molecules in the context of cancer immunotherapy and immunology. This monoclonal antibody, specific to CD274 (also known as PD-L1), is conjugated to allophycocyanin (APC), enabling easy detection and analysis in flow cytometry and other applications.CD274, or Programmed Death-Ligand 1 (PD-L1), is a key immune checkpoint protein that plays a crucial role in regulating T-cell responses and immune tolerance. By binding to its receptor PD-1 on T cells, PD-L1 helps tumors evade immune detection and suppresses immune responses in the tumor microenvironment. Targeting the PD-1/PD-L1 pathway has revolutionized cancer treatment, leading to the development of immune checkpoint inhibitors that unleash the immune system to attack cancer cells.

This monoclonal antibody, clone 10F.9G2, specifically recognizes mouse CD274/PD-L1, making it an essential tool for studying the expression and function of PD-L1 in various experimental models. Its APC conjugation allows for precise and sensitive detection of PD-L1 expression on different cell types, facilitating detailed analysis of immune responses and tumor immunity.Research using this antibody can provide insights into the mechanisms of immune evasion by tumors, the role of PD-L1 in immune checkpoints, and the potential for immunotherapy targeting the PD-1/PD-L1 axis in cancer. By understanding the complex interactions involving PD-L1, researchers can advance the development of novel immunotherapies and personalized treatment strategies for cancer patients.

Product Title:APC Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
SKU:AGEL1640
Size:50 Tests, 100 Tests, 200 Tests
Clone No:10F.9G2
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:APC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q9EP73
Gene ID:60533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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