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PE/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL0725)

SKU:
AGEL0725
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€259 - €609
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1]

The Mouse CD22 Monoclonal Antibody PE/Cyanine5.5 Conjugated (CY34-1) is a specialized research tool offered by Assay Genie for studies involving the CD22 antigen. This antibody is specifically designed for flow cytometry applications and is conjugated with PE/Cyanine5.5 for efficient detection and analysis of CD22 in various cell samples.CD22 is a cell surface glycoprotein primarily found on B cells and plays a crucial role in regulating B cell activation and survival. By targeting CD22 with the CY34-1 antibody, researchers can effectively study B cell function, development, and related processes in immunology and cancer research.

The conjugation with PE/Cyanine5.5 allows for multi-color flow cytometry experiments, enabling detailed analysis of CD22 expression in complex cell populations.The CY34-1 antibody provides high specificity and sensitivity in detecting CD22, making it a valuable tool for researchers investigating B cell-related diseases, immunodeficiencies, and therapeutic targets. With its optimized performance in flow cytometry, this antibody facilitates precise and reliable data collection for advancements in biomedical research and drug development.

Product Title:PE/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL0725
Size:50 Tests, 100 Tests, 200 Tests
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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