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GenieFluor 488 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL0727)

SKU:
AGEL0727
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€259 - €609
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD22 Antibody [Cy34.1]

The Mouse CD22 Monoclonal Antibody (AF488 Conjugated) CY34.1 is a specialized antibody from Assay Genie designed for research purposes involving the CD22 protein. CD22 is a cell surface glycoprotein that plays a crucial role in B-cell function and regulation. This monoclonal antibody, conjugated with AF488 for fluorescence detection, is optimized for use in flow cytometry and fluorescence microscopy applications.The antibody, generated using the CY34.1 hybridoma cell line, offers high specificity and sensitivity for detecting CD22 in mouse samples. It enables researchers to study the expression and localization of CD22 in various biological samples, aiding in the investigation of B-cell development, activation, and response to stimuli.

CD22 is a key target for research in immunology, particularly in understanding B-cell signaling pathways and their dysregulation in diseases such as leukemia, lymphoma, and autoimmune disorders. By utilizing the Mouse CD22 Monoclonal Antibody (AF488 Conjugated) CY34.1, researchers can gain valuable insights into the role of CD22 in these conditions, paving the way for the development of targeted therapies and diagnostic tools.

Product Title:GenieFluor 488 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL0727
Size:50 Tests, 100 Tests, 200 Tests
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:Genie Fluor 488 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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