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PE Anti-Mouse CD206 Antibody [C068C2] (AGEL1655)

SKU:
AGEL1655
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€219 - €619
Frequently bought together:

Description

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PE Anti-Mouse CD206 Antibody [C068C2]

The Mouse CD206 Monoclonal Antibody (PE Conjugated, C068C2-AGEL1655) is a powerful tool for researchers studying CD206, a cell surface receptor known for its role in immune response modulation. This monoclonal antibody, conjugated to Phycoerythrin (PE), offers high specificity and sensitivity in detecting CD206 expression in mouse samples.CD206, also called the macrophage mannose receptor, is involved in various immune processes, including antigen presentation and inflammation regulation. By targeting and binding to CD206, this antibody allows for accurate detection and analysis of CD206-expressing cells in diverse experimental settings.

It is particularly valuable for investigations in immunology, inflammation, and infectious diseases research.The precise binding capability of this monoclonal antibody makes it a valuable asset for scientists studying the function and regulation of CD206 in mouse models. By gaining insights into the roles of CD206 in immune responses, researchers can advance their understanding of diseases such as cancer, infectious diseases, and inflammatory disorders, potentially leading to the development of novel therapeutic strategies.

Product Title:PE Anti-Mouse CD206 Antibody [C068C2]
SKU:AGEL1655
Size:25µg, 100µg
Clone No:C068C2
Synonyms:MMR;MR;MRC1;macrophage mannose receptor;mannose receptor ;
Host Species:Rat
Reactivity:Mouse
Application:FCM;ICFCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q61830
Gene ID:17533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

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