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Mouse CD18 monoclonal antibody (FITC) (AGIM0500)

SKU:
AGIM0500
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
M18/2
Conjugation:
FITC
Applications:
FC
$215
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Description

system_update_altDatasheet
Product Name:Mouse CD18 monoclonal antibody (FITC)
Product Code:AGIM0500
Size:100 µL
Reactivity:Mouse
Clone:M18/2
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG2a
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P05107
Background:CD18 is a 95 kD protein, also known as integrin ??2 subunit. It is expressed on all leukocytes. CD18, in association with integrin ?± chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and ?±X??2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. The M18/2 antibody is able to block tumor cell metastasis and enhance cell adhesion.
UniProt Protein Function:ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.; Cell surface; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cell surface; membrane; plasma membrane; integrin complex; receptor complex; vesicle; lipid raft

Molecular Function:protein binding; protein heterodimerization activity; metal ion binding; protein complex binding; cell adhesion molecule binding; ICAM-3 receptor activity; glycoprotein binding; protein kinase binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of nitric oxide biosynthetic process; apoptosis; cell-matrix adhesion; natural killer cell activation; receptor clustering; activation of NF-kappaB transcription factor; regulation of cell shape; leukocyte adhesion; cellular extravasation; cell-cell signaling; inflammatory response; cell adhesion; toll-like receptor 4 signaling pathway; regulation of peptidyl-tyrosine phosphorylation; aging; integrin-mediated signaling pathway; neutrophil chemotaxis; regulation of immune response; activated T cell proliferation; leukocyte migration during inflammatory response; heterotypic cell-cell adhesion; positive regulation of angiogenesis; toll-like receptor signaling pathway; innate immune response; endothelial cell migration; blood coagulation; leukocyte migration

Disease: Leukocyte Adhesion Deficiency, Type I

NCBI Summary:This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Code:P05107
NCBI GenInfo Identifier:124056465
NCBI Gene ID:3689
NCBI Accession:P05107.2
UniProt Secondary Accession:P05107,Q16418, Q53HS5, Q9UD72, B3KTS8, D3DSM1,
UniProt Related Accession:P05107
Molecular Weight:769
NCBI Full Name:Integrin beta-2
NCBI Synonym Full Names:integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
NCBI Official Symbol:ITGB2  
NCBI Official Synonym Symbols:LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1  
NCBI Protein Information:integrin beta-2; integrin beta chain, beta 2; complement receptor C3 beta-subunit; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor)
UniProt Protein Name:Integrin beta-2
UniProt Synonym Protein Names:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18
Protein Family:Integrin
UniProt Gene Name:ITGB2  
UniProt Entry Name:ITB2_HUMAN

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