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GenieFluor 647 Anti-Mouse CD162 Antibody [4RA10] (AGEL0855)

SKU:
AGEL0855
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€199 - €459
Frequently bought together:

Description

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GenieFluor 647 Anti-Mouse CD162 Antibody [4RA10]

The Mouse CD162 Monoclonal Antibody (AF647 Conjugated, 4RA10, AGEL0855) offered by Assay Genie is a cutting-edge tool for researchers delving into immune system function and cell surface interactions. This antibody specifically targets CD162, a molecule implicated in various immune processes and cell adhesion. With its AF647 conjugation, this antibody is equipped for fluorescent detection methods, providing a clear and precise visualization of CD162 expression in cell samples.Derived from mouse monoclonal sources, this antibody boasts high specificity and sensitivity, making it a reliable choice for applications such as flow cytometry and immunofluorescence.

The ability to detect and analyze CD162 expression in different cell types enables researchers to explore the role of this molecule in diverse biological contexts, ranging from immune responses to inflammatory conditions.The CD162 Monoclonal Antibody from Assay Genie opens up avenues for detailed investigations into the functions and mechanisms of CD162, shedding light on its involvement in immune regulation and cellular interactions. Whether studying immune responses, cell adhesion processes, or immune-related diseases, this antibody provides a valuable tool for advancing research in immunology and beyond.

Product Title:GenieFluor 647 Anti-Mouse CD162 Antibody [4RA10]
SKU:AGEL0855
Size:25µg, 100µg
Clone No:4RA10
Synonyms:P-selectin glycoprotein ligand 1;Selplg;PSGL-1;Selectin P ligand;CD162;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:Genie Fluor 647 Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62170
Gene ID:20345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.

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