null

GenieFluor 488 Anti-Mouse CD162 Antibody [4RA10] (AGEL0854)

SKU:
AGEL0854
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€209 - €489
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

GenieFluor 488 Anti-Mouse CD162 Antibody [4RA10]

The Mouse CD162 Monoclonal Antibody (AF488 Conjugated, 4RA10) available at assaygenie.com is a vital tool for researchers studying CD162, a cell surface molecule with important implications in immune responses. This monoclonal antibody is conjugated with AF488, a fluorescent dye, allowing for easy visualization and detection in experiments.CD162, also known as PSGL-1, is involved in various immune processes such as leukocyte rolling and adhesion during inflammation. This specific antibody, developed for use with mouse samples, offers high specificity and sensitivity in detecting CD162 in different cell types, making it ideal for immunology and inflammation research.

By targeting CD162, researchers can gain insight into how immune cells interact and respond to inflammatory signals, providing a deeper understanding of conditions like inflammation, infection, and immune-mediated diseases. This antibody is a valuable tool for investigating the role of CD162 in immune regulation and developing potential therapeutic strategies targeting this molecule for various diseases.

Product Title:GenieFluor 488 Anti-Mouse CD162 Antibody [4RA10]
SKU:AGEL0854
Size:25µg, 100µg
Clone No:4RA10
Synonyms:P-selectin glycoprotein ligand 1;Selplg;PSGL-1;Selectin P ligand;CD162;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:Genie Fluor 488 Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q62170
Gene ID:20345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.

Related Products