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FITC Anti-Mouse CD161/NK1.1 Antibody [PK136] (AGEL0484)

SKU:
AGEL0484
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
PK136
Conjugation:
FITC
$107 - $167
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Description

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FITC Anti-Mouse CD161/NK1.1 Antibody [PK136]

The Mouse CD161/NK1.1 Monoclonal Antibody (FITC Conjugated) PK136 (AGEL0484) is a specialized antibody tailored for research involving CD161/NK1.1, key cell surface markers associated with natural killer (NK) cells and other immune cells. This monoclonal antibody, engineered for use in mouse samples, is conjugated with FITC for easy and efficient detection in flow cytometry and immunofluorescence applications.CD161/NK1.1 serves as a crucial marker for identifying and studying NK cells, a vital component of the innate immune system responsible for recognizing and eliminating infected or abnormal cells. By targeting this specific antigen, researchers can delve into the functions and behaviors of NK cells in various biological processes such as immune responses to pathogens, tumor surveillance, and autoimmunity.The PK136 monoclonal antibody offers high specificity and sensitivity for CD161/NK1.

1, allowing for precise detection and analysis of NK cells and other CD161/NK1.1-expressing cell populations. Its compatibility with flow cytometry and immunofluorescence techniques enables detailed characterization of immune cell subsets and facilitates in-depth investigations into the role of CD161/NK1.1 in immune responses and disease pathogenesis.With its tailored design for mouse samples and FITC conjugation for fluorescence-based assays, the Mouse CD161/NK1.1 Monoclonal Antibody (FITC Conjugated) PK136 (AGEL0484) is a valuable tool for immunologists, cell biologists, and researchers exploring the intricate mechanisms of NK cell biology, immune function, and related diseases. This antibody opens up new avenues for advancing our understanding of immune cell dynamics and developing targeted strategies for immunotherapy and disease intervention.

Product Title:FITC Anti-Mouse CD161/NK1.1 Antibody [PK136]
SKU:AGEL0484
Size:25µg, 100µg
Clone No:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C;Klrb1c;CD161 antigen-like family member C;Ly-55c;CD161/NK1.1;NKR-P1.9;NKR-P1C;NKR-P1 40;CD161c;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:FITC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P27814 P27812 Q99JB4
Gene ID:17059
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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