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Purified Anti-Mouse CD132 Antibody [3E12] (AGEL0105)

SKU:
AGEL0105
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
3E12
Conjugation:
Unconjugated
Applications:
FC
$119 - $239
Frequently bought together:

Description

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Purified Anti-Mouse CD132 Antibody [3E12]

The Mouse CD132 Monoclonal Antibody (3E12) is a powerful tool for researchers studying immune system modulation and signal transduction pathways. This antibody, produced by AssayGenie, specifically targets CD132, also known as the common gamma chain, which plays a crucial role in cytokine receptor signaling.With its high reactivity with mouse samples, this monoclonal antibody is ideal for various immunological studies, including flow cytometry, immunoprecipitation, and immunohistochemistry. By binding to CD132, researchers can effectively detect and analyze the expression and activation of this important protein in different cell types and tissues.CD132 is a key component of several cytokine receptors, including those for interleukins 2, 4, 7, 9, 15, and 21, making it essential for various immune responses and T cell development.

Dysregulation of CD132 signaling has been implicated in immune disorders and certain types of cancer, underscoring the significance of studying this protein in research settings.By utilizing the Mouse CD132 Monoclonal Antibody (3E12) from AssayGenie, researchers can gain valuable insights into immune system function, cytokine signaling pathways, and potential therapeutic targets for immune-related diseases. This antibody is a valuable tool for advancing scientific understanding in immunology, oncology, and related fields.

Product Title:Purified Anti-Mouse CD132 Antibody [3E12]
SKU:AGEL0105
Size:25µg, 100µg
Clone No:3E12
Synonyms:Cytokine receptor common subunit gamma;Il2rg;Interleukin-2 receptor subunit gamma;IL-2 receptor subunit gamma;IL-2R subunit gamma;IL-2RG;gammaC;p64;CD132;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P34902
Gene ID:16186
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common γ chain (γc) or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).

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