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Biotin Anti-Mouse CD120b Antibody [TR75-54.7] (AGEL0162)

SKU:
AGEL0162
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Hamster
Isotype:
IgG
Clone:
TR75-54.7
Conjugation:
Biotin
Applications:
FC
€149 - €219
Frequently bought together:

Description

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Biotin Anti-Mouse CD120b Antibody [TR75-54.7]

The Mouse CD120b Monoclonal Antibody (Biotin Conjugated) TR75-54.7 (AGEL0162) is a valuable tool for researchers studying CD120b, also known as the tumor necrosis factor receptor 2 (TNFR2). This antibody, derived from a hybridoma cell line, is specifically designed for use in detecting and analyzing CD120b protein expression in mouse samples. Its biotin conjugation provides a versatile means of detection, making it suitable for applications such as immunohistochemistry and flow cytometry.CD120b, a receptor for tumor necrosis factor (TNF), plays a crucial role in mediating immune responses, inflammation, and cell survival. By targeting CD120b, researchers can investigate its involvement in various physiological and pathological processes, including autoimmune diseases, infectious diseases, and cancer.

Understanding the function and regulation of CD120b is vital for developing targeted therapies that can modulate TNF signaling pathways and potentially treat a range of inflammatory disorders.The Mouse CD120b Monoclonal Antibody (Biotin Conjugated) TR75-54.7 (AGEL0162) offers high specificity and sensitivity, making it a reliable tool for elucidating the role of CD120b in immune system functions and disease pathways. Its application extends to in vitro and in vivo studies, providing valuable insights into the mechanisms underlying immune responses and inflammatory conditions. Researchers in immunology, oncology, and related fields can leverage this antibody to advance their understanding of TNFR2 signaling and its implications for human health.

Product Title:Biotin Anti-Mouse CD120b Antibody [TR75-54.7]
SKU:AGEL0162
Size:25µg, 100µg
Clone No:TR75-54.7
Synonyms:Tumor necrosis factor receptor superfamily member 1B;Tnfrsf1b;Tumor necrosis factor receptor 2;TNF-R2;TNF-RII;TNFR-II;p75;p80 TNF-alpha receptor;CD120b;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Isotype Control:Biotin Armenian Hamster IgG Isotype Control[PIP]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P25119
Gene ID:21938
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-α and LT-α (also known as TNF-β). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.

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