Biotin Anti-Mouse CD119 Antibody [GR-20] (AGEL0434)
- SKU:
- AGEL0434
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rat
- Isotype:
- IgG2a
- Clone:
- GR-20
- Conjugation:
- Biotin
- Applications:
- FC
Frequently bought together:
Description
Product Title: | Biotin Anti-Mouse CD119 Antibody [GR-20] |
SKU: | AGEL0434 |
Size: | 25µg, 100µg |
Clone No: | GR-20 |
Synonyms: | Interferon gamma receptor 1;Ifngr1;IFN-gamma-R1;IFN-gamma-R-alpha;CD119; |
Host Species: | Rat |
Reactivity: | Mouse |
Application: | FCM |
Isotype: | Rat IgG2a, κ |
Isotype Control: | Biotin Rat IgG2a, κ Isotype Control[2A3] |
Form: | Liquid |
Conjugation: | Biotin |
Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Swissprot: | P15261 |
Gene ID: | 15979 |
Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Stability & Storage: | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Background: | CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-γRα chain. It is a class II cytokine receptor family member that serves as a IFN-γ-binding chain associated with the IFN-γ β chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses. |