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APC Anti-Mouse CD117 Antibody [2B8] (AGEL1187)

SKU:
AGEL1187
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€169 - €369

Description

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APC Anti-Mouse CD117 Antibody [2B8]

The Mouse CD117 Monoclonal Antibody (APC Conjugated, 2B8) (AGEL1187) is a valuable tool for researchers studying CD117, a cell surface receptor involved in cell signaling and differentiation. This antibody, specifically designed for use in flow cytometry applications, is raised in mice and exhibits high reactivity with mouse samples.CD117, also known as c-kit or stem cell factor receptor, plays a crucial role in various cellular processes, including hematopoiesis, melanogenesis, and gametogenesis. Its expression is widely observed in stem cells, progenitor cells, and certain cancer cells, making it a valuable marker for identifying and characterizing these cell populations.

The APC conjugation of this monoclonal antibody allows for easy detection and quantification of CD117 expression in different cell types, providing valuable insights into stem cell biology, developmental processes, and malignant transformation. Researchers in fields such as cell biology, oncology, and regenerative medicine will find this antibody essential for their studies on CD117-mediated signaling pathways and cellular functions.

Product Title:APC Anti-Mouse CD117 Antibody [2B8]
SKU:AGEL1187
Size:25µg, 100µg
Clone No:2B8
Synonyms:Mast/stem cell growth factor receptor Kit;Kit;SCFR;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;CD117;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:APC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P05532
Gene ID:16590
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

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