null

PE/Cyanine7 Anti-Mouse CD103 Antibody [M290] (AGEL1158)

SKU:
AGEL1158
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€269 - €619
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

PE/Cyanine7 Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody PE-Cyanine7 Conjugated (M290) is a specialized tool designed for researchers involved in studying CD103, a crucial cell surface molecule involved in immune responses and cell adhesion. This monoclonal antibody, conjugated with PE-Cyanine7 for enhanced detection capabilities, is specifically tailored for mouse samples and is validated for use in flow cytometry applications.CD103, also known as integrin alpha E, plays a pivotal role in immune surveillance, particularly in tissue-resident immune cells such as intraepithelial lymphocytes. Its expression is closely associated with immune tolerance and inflammation regulation within the mucosal immune system. The M290 monoclonal antibody specifically targets CD103, facilitating precise detection and analysis in a variety of cell types, making it an invaluable tool for researchers exploring immunology, mucosal immunology, and inflammatory responses in diverse experimental settings.

By utilizing the Mouse CD103 Monoclonal Antibody PE-Cyanine7 Conjugated (M290), researchers can delve deeper into the mechanisms underlying immune regulation, tissue-specific immunity, and inflammatory processes. This antibody provides a reliable means to study the expression and function of CD103 in mouse models, offering insights that could be essential in the development of novel therapeutic strategies for immune-related disorders and inflammatory conditions.

Product Title:PE/Cyanine7 Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1158
Size:25µg, 100µg
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

Related Products