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PE/Cyanine7 Anti-Mouse CD103 Antibody [M290] (AGEL1149)

SKU:
AGEL1149
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€389 - €889
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody PE-Cyanine7 Conjugated (M290) - AGEL1149 is a powerful tool designed for researchers studying immune cell populations in mice. This antibody specifically targets CD103, a cell surface marker associated with tissue-resident memory T cells in the immune system. The M290 antibody, conjugated with PE-Cyanine7 for easy detection and analysis, is a high-quality reagent that has been extensively validated for flow cytometry applications. Its ability to selectively bind to CD103 allows for precise identification and characterization of CD103-expressing cells in various tissues and experimental conditions.CD103 is known to play a crucial role in immune surveillance and response, particularly in tissues exposed to pathogens or inflammation.

By targeting CD103 with this monoclonal antibody, researchers can gain valuable insights into the function and behavior of tissue-resident T cells, paving the way for a deeper understanding of immune responses and potential therapeutic interventions.Ideal for immunology studies, inflammation research, and investigations into host-pathogen interactions, the Mouse CD103 Monoclonal Antibody PE-Cyanine7 Conjugated (M290) - AGEL1149 is a versatile tool that promises reliable and reproducible results in diverse experimental settings.

Product Title:PE/Cyanine7 Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1149
Size:50 Tests, 100 Tests, 200 Tests
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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