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PE/Cyanine5 Anti-Mouse CD103 Antibody [M290] (AGEL1148)

SKU:
AGEL1148
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
M290
Conjugation:
PE/Cy5
€389 - €889
Frequently bought together:

Description

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PE/Cyanine5 Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody (PE/Cyanine5 Conjugated) - M290 (AGEL1148) offered by Assay Genie is an essential tool for research focusing on CD103, a cell surface molecule known for its role in immune regulation and immune cell trafficking in tissues. This antibody, monoclonal in origin, is specifically designed for use with mouse samples and is ideal for flow cytometry applications.CD103, also referred to as αE integrin, is recognized for its involvement in tissue residency of immune cells, particularly in the context of inflammation and immune surveillance. By targeting CD103, researchers can study the behavior and distribution of immune cells expressing this molecule, providing insights into immune responses in various tissues and disease states.

This antibody enables precise detection and analysis of CD103-expressing cells, making it a valuable asset for studies in immunology, tissue biology, and pathology.Understanding the functions and interactions of CD103 is essential for unraveling the complexities of immune cell behavior within tissues, shedding light on mechanisms underlying immune responses, tolerance, and immune-mediated pathologies. The availability of a reliable and specific antibody like the Mouse CD103 Monoclonal Antibody (PE/Cyanine5 Conjugated) - M290 (AGEL1148) facilitates in-depth investigations into the roles of CD103 in health and disease, paving the way for advancements in immunotherapy and disease treatment strategies.

Product Title:PE/Cyanine5 Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1148
Size:50 Tests, 100 Tests, 200 Tests
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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