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APC Anti-Mouse CD103 Antibody [M290] (AGEL1155)

SKU:
AGEL1155
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€189 - €489
Frequently bought together:

Description

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APC Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody (APC-conjugated, M290) from Assay Genie (Catalog #AGEL1155) is a powerful tool for researchers investigating immune responses in various biological systems. This monoclonal antibody, specifically targeting the CD103 antigen, is conjugated to allophycocyanin (APC) for easy detection and analysis in flow cytometry and immunofluorescence applications.CD103, also known as alpha E integrin, is a cell surface glycoprotein involved in the regulation of immune responses, particularly in the context of tissue residency and immune cell migration. It plays a crucial role in mediating interactions between immune cells and the surrounding microenvironment, making it a key target for studies focusing on immune surveillance, tolerance, and inflammation.By utilizing the Mouse CD103 Monoclonal Antibody (APC-conjugated, M290) in your research, you can accurately identify and quantify CD103-expressing cells in tissues and blood samples, aiding in the understanding of immune cell dynamics and disease pathogenesis.

This antibody is rigorously tested and validated for specificity and sensitivity, ensuring reliable results and reproducibility in your experiments.Whether investigating immune responses in cancer, autoimmunity, or infectious diseases, the Mouse CD103 Monoclonal Antibody (APC-conjugated, M290) provides a valuable tool for elucidating the intricate mechanisms governing immune regulation and tissue-specific immunity. Trust Assay Genie for high-quality antibodies that drive groundbreaking discoveries in immunology and beyond.

Product Title:APC Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1155
Size:25µg, 100µg
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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