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GenieFluor 647 Anti-Mouse CD103 Antibody [M290] (AGEL1162)

SKU:
AGEL1162
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
M290
Conjugation:
AF 647
€199 - €409
Frequently bought together:

Description

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GenieFluor 647 Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody (AF647 Conjugated, M290 - AGEL1162) offered by Assay Genie is a cutting-edge tool designed for researchers investigating CD103, a crucial cell surface molecule known for its role in immune regulation. This monoclonal antibody, conjugated with AF647, provides highly specific and sensitive detection of CD103 in mouse samples, making it a versatile resource for various immunological studies.CD103, also known as αEβ7 integrin, is involved in tissue-specific immune responses, particularly in mucosal immunity and tolerance induction. Its expression on intraepithelial T cells is a key marker for tissue-resident memory T cells in epithelial surfaces such as the gut and skin. By utilizing the AF647-conjugated M290 antibody, researchers can accurately identify and analyze CD103-expressing cells in experimental settings, aiding in the investigation of immune responses in various tissues and disease models.The M290 antibody's specificity for mouse CD103, coupled with the fluorescence detection enabled by the AF647 conjugation, allows for precise visualization and quantification of CD103-positive cells in flow cytometry, immunofluorescence, and other relevant assays.

This product is rigorously validated for its performance and reliability in experimental applications, ensuring consistent and reproducible results for researchers studying immune responses, inflammation, tissue immunity, and other related areas.In summary, the Mouse CD103 Monoclonal Antibody (AF647 Conjugated, M290 - AGEL1162) from Assay Genie is a state-of-the-art solution for scientists exploring the functions and roles of CD103 in the immune system. With its high specificity, sensitivity, and versatility, this antibody is an essential tool for advancing research in immunology, mucosal immunity, and related fields, providing valuable insights into immune regulation and tissue-specific immune responses in experimental models.

Product Title:GenieFluor 647 Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1162
Size:25µg, 100µg
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 647 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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