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GenieFluor 488 Anti-Mouse CD103 Antibody [M290] (AGEL1161)

SKU:
AGEL1161
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
M290
Conjugation:
AF 488
€199 - €409
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD103 Antibody [M290]

The Mouse CD103 Monoclonal Antibody (AF488 Conjugated) is a powerful tool for researchers studying immune cell interactions and tissue specificity. This antibody specifically targets CD103, a cell surface marker expressed on a subset of dendritic cells and intraepithelial lymphocytes. The AF488 conjugation allows for easy visualization and detection of CD103 in immunofluorescence and flow cytometry applications.CD103 is involved in regulating immune responses and promoting tissue-resident memory in various contexts, including gut mucosa and tumor microenvironments. By specifically binding to CD103, this monoclonal antibody enables researchers to investigate the role of this molecule in immune surveillance, tolerance, and anti-tumor immunity.

Its compatibility with mouse samples ensures accurate and reliable results in experimental settings focused on immune cell migration, gut immunity, and tumor immunology.Whether exploring immune cell dynamics in the gut epithelium or investigating the impact of CD103 on anti-tumor immunity, this AF488-conjugated monoclonal antibody offers a valuable tool for advancing research in immunology, cancer biology, and tissue-specific immune responses. Trust in its specificity and performance to shed light on the intricate roles of CD103 in immune regulation and disease pathogenesis.

Product Title:GenieFluor 488 Anti-Mouse CD103 Antibody [M290]
SKU:AGEL1161
Size:25µg, 100µg
Clone No:M290
Synonyms:Integrin alpha-E;Itgae;Integrin alpha M290;CD103;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q60677
Gene ID:16407
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.

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