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Mouse APOA1 Recombinant Protein (RPPB0046)

SKU:
RPPB0046
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q00623
Research Area:
Cytokines
€309
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Description

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Product Name:Mouse APOA1 Recombinant Protein
Product Code:RPPB0046
Size:20µg
Species:Mouse
Target:APOA1
Synonyms:ApolipoproteinA-I, Apo-AI, ApoA-I, Apolipoprotein A1, ProapoA-I.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:APOA1 protein solution (1mg/ml) containing Phosphatebuffered saline (pH7.4), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSDEPQSQWDKVKDFANVY VDAVKDSGRD YVSQFESSSL GQQLNLNLLE NWDTLGSTVS QLQERLGPLT RDFWDNLEKETDWVRQEMNK DLEEVKQKVQ PYLDEFQKKW KEDVELYRQK VAPLGAELQE SARQKLQELQ GRLSPVAEEFRDRMRTHVDS LRTQLAPHSE QMRESLAQRL AELKSNPTLN EYHTRAKTHL KTLGEKARPA LEDLRHSLMPMLETLKTQVQ SVIDKASETL TAQ

APOA1 (Apolipoprotein A-1) is a protein with a specific role in lipid metabolism being the main protein component of HDL in the plasma. APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Furthermore, APOA1 is a cofactor for LCAT, which is responsible for the formation of most plasma cholesteryl esters. In addition, APOA1 activates spermatozoa motility as part of the SPAP complex. The APOA1 gene is strongly linked with two other apolipoprotein genes on chromosome 11. Defects in the APOA1 gene are linked to HDL deficiency including Tangier disease, and with systemic non-neuropathic amyloidosis. High levels of APOA1 are linked to the manifestation of asthma and atopy.

APOA1 Mouse Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 263 amino acids (25-264a.a) andhaving a molecular mass of 30.3kDa.APOA1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
NCBI Summary:This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is the major protein component of plasma high density lipoprotein (HDL). This protein facilitates the removal of cholesterol and other fats from tissues by transporting them to the liver for excretion. This protein is a cofactor for lecithin cholesterolacyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. Mutations in this gene in humans causes familial HDL deficiency, Tangier disease and familial visceral amyloidosis. Similar clinical features are exhibited by mice with mutations in this gene. This gene is clustered with three other apolipoprotein genes on chromosome 9. [provided by RefSeq, Dec 2013]
UniProt Code:Q00623
NCBI GenInfo Identifier:160333304
NCBI Gene ID:11806
NCBI Accession:NP_033822
UniProt Secondary Accession:Q00623,O08855, O09042, Q8BPD5,
UniProt Related Accession:Q00623
Molecular Weight:30.3kDa (263aa) confirmed by MALDI-TOF
NCBI Full Name:apolipoprotein A-I preproprotein
NCBI Synonym Full Names:apolipoprotein A-I
NCBI Official Symbol:Apoa1��
NCBI Official Synonym Symbols:Sep2; Alp-1; Ltw-1; Sep-1; Sep-2; Apoa-1; Brp-14; Lvtw-1; apo-AI; apoA-I��
NCBI Protein Information:apolipoprotein A-I
UniProt Protein Name:Apolipoprotein A-I
UniProt Synonym Protein Names:Apolipoprotein A1
Protein Family:Apolipoprotein
UniProt Gene Name:Apoa1��

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