The Monomethyl YAP1 (K342) Polyclonal Antibody (CAB18651) is a valuable tool for researchers studying the activity of the YAP1 protein, a key regulator of cell growth and organ size. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. It specifically targets the monomethylated form of the YAP1 protein at lysine 342, enabling precise detection and analysis in various cell types.YAP1, a transcriptional coactivator, plays a crucial role in controlling gene expression pathways involved in cell proliferation, survival, and tissue regeneration. Dysregulation of YAP1 is associated with various diseases, including cancer, making it an attractive target for therapeutic interventions.
Research on the monomethylated form of YAP1 at lysine 342 provides insights into its post-translational modifications and their impact on cellular signaling pathways.By utilizing the Monomethyl YAP1 (K342) Polyclonal Antibody (CAB18651), researchers can delve deeper into the mechanisms governing YAP1 activity and its implications for disease development and progression. This antibody is an essential tool for unraveling the complexities of YAP1 biology and exploring its therapeutic potential in cancer and regenerative medicine research.
Product Name:
MonoMethyl-YAP1-K342 Rabbit Polyclonal Antibody
SKU:
CAB18651
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic monomethylated peptide around K342 of human YAP1 (NP_001123617.1).
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10413
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MonoMethyl-YAP1-K342 Rabbit pAb (CAB18651) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
