The Monomethyl Histone H3R2 Rabbit Monoclonal Antibody (CAB19645) is a high-quality antibody designed for research involving histone modifications, specifically the monomethylation of histone H3 at arginine 2 (H3R2). This antibody, raised in rabbits, is highly specific and sensitive for detecting the monomethyl histone H3R2 modification in various cell types and tissues.Histone modifications, including methylation at specific residues, play a crucial role in regulating gene expression and chromatin structure. The monomethylation of histone H3R2 is involved in transcriptional regulation and has been linked to various cellular processes, including development, differentiation, and disease.
The Monomethyl Histone H3R2 Rabbit Monoclonal Antibody is validated for use in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation. Its specificity and reliability make it a valuable tool for researchers studying epigenetics, gene regulation, and chromatin dynamics in both normal and disease states.By using this antibody, researchers can gain insights into the role of histone modifications, specifically monomethyl histone H3R2, in various biological processes and diseases, paving the way for the development of potential therapeutic interventions targeting epigenetic mechanisms.
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Purification Method:
Affinity purification
Gene ID:
8290/8350
Clone Number:
ARC0124
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
CUT&Tag was performed using the CUT&Tag Assay Kit (pAG-Tn5) for Illumina(RK20265) from 10⁵ K562 cells with 1 μg MonoMethyl-Histone H3-R2 antibody (CAB19645) , along with a Goat Anti-Rabbit IgG(H+L). The CUT&Tag results indicate the enrichment pattern of H3R2me1 in representative gene loci (MYOD1), as shown in figure.
