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Anti-Monoamine Oxidase A Antibody (CAB4105)

SKU:
CAB4105
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-Monoamine Oxidase A Antibody
Antibody SKU:CAB4105
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Monoamine Oxidase A
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse lung, Mouse brain, Mouse kidney, Rat liver
Immunogen:A synthesized peptide derived from human Monoamine Oxidase A
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4128
Uniprot:P21397
Cellular Location:
Calculated MW:60kDa
Observed MW:60KDa
Synonyms:BRNRS, MAO-A
Background:This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
UniProt Protein Function:MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family.
UniProt Protein Details:

Protein type:EC 1.4.3.4; Membrane protein, integral; Amino Acid Metabolism - tryptophan; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: Xp11.3

Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane

Molecular Function:amine oxidase activity

Biological Process: synaptic transmission; biogenic amine metabolic process; neurotransmitter catabolic process; dopamine catabolic process; xenobiotic metabolic process; neurotransmitter secretion; neurotransmitter biosynthetic process

Disease: Brunner Syndrome

NCBI Summary:This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
UniProt Code:P21397
NCBI GenInfo Identifier:113978
NCBI Gene ID:4128
NCBI Accession:P21397.1
UniProt Secondary Accession:P21397,Q16426, B4DF46,
UniProt Related Accession:P21397
Molecular Weight:527
NCBI Full Name:Amine oxidase
NCBI Synonym Full Names:monoamine oxidase A
NCBI Official Symbol:MAOA  
NCBI Official Synonym Symbols:MAO-A  
NCBI Protein Information:amine oxidase [flavin-containing] A; amine oxidase [flavin-containing] A; monoamine oxidase type A
UniProt Protein Name:Amine oxidase [flavin-containing] A
UniProt Synonym Protein Names:Monoamine oxidase type A; MAO-A
Protein Family:Amine oxidase
UniProt Gene Name:MAOA  
UniProt Entry Name:AOFA_HUMAN
Anti-Monoamine Oxidase A Antibody (CAB4105)Western blot - Monoamine Oxidase A Rabbit mAb (CAB4105)

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