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Mono-Methyl-Histone H2B (Lys5) Antibody (PACO00146)

SKU:
PACO00146
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Mono-Methyl-Histone H2B (Lys5) Antibody (PACO00146)

The Mono-Methyl Histone H2B Lys5 Antibody (PACO00146) is a highly specific and sensitive tool for researchers studying epigenetic modifications. This polyclonal antibody, generated in rabbits, is optimized for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.Histone H2B Lys5 methylation plays a crucial role in gene regulation and chromatin structure, and aberrant methylation at this site has been implicated in various diseases, including cancer and developmental disorders. The Mono-Methyl Histone H2B Lys5 Antibody binds specifically to the mono-methylated form of histone H2B at lysine 5, allowing for precise detection and quantification in different cell types and experimental conditions.

By using the Mono-Methyl Histone H2B Lys5 Antibody, researchers can investigate the impact of histone methylation on gene expression, chromatin remodeling, and cellular processes. This antibody is a valuable tool for epigenetics and chromatin biology research, offering insight into the mechanisms underlying disease development and progression.

Antibody Name:Mono-Methyl-Histone H2B (Lys5) Antibody
Antibody SKU:PACO00146
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthetic Peptide
Form:Liquid
Storage Buffer:PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:Affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:HIST1H2BA; TSH2B; Histone H2B type 1-A; Histone H2B, testis; Testis-specific histone H2B; HIST1H2BB; H2BFF; Histone H2B type 1-B; Histone H2B.1; Histone H2B.f; H2B/f; HIST1H2BC; H2BFL; HIST1H2BE; H2BFH; HIST1H2BF; H2BFG; HIST1H2BG; H2BFA; HIST1H2BI; H2BFK
UniProt Protein Function:H2B1A: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Transcribed exclusively in testis, and the corresponding protein is also present in mature sperm. Belongs to the histone H2B family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p22.2Cellular Component: extrinsic to plasma membrane; nuclear chromosome, telomeric region; nucleoplasm; nucleosome; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: establishment and/or maintenance of chromatin architecture; inflammatory response; nucleosome assembly; nucleosome disassembly; plasminogen activation; positive regulation of binding; spermatogenesis, exchange of chromosomal proteins
UniProt Protein Details:
NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
UniProt Code:Q96A08
NCBI GenInfo Identifier:51316070
NCBI Gene ID:255626
NCBI Accession:Q96A08.3
UniProt Secondary Accession:Q96A08,Q6NZ98, Q6NZA0, Q6NZA1, B2R544
UniProt Related Accession:Q96A08
Molecular Weight:14,167 Da
NCBI Full Name:Histone H2B type 1-A
NCBI Synonym Full Names:histone cluster 1, H2ba
NCBI Official Symbol:HIST1H2BA  
NCBI Official Synonym Symbols:STBP; TH2B; H2BFU; TSH2B; TSH2B.1; bA317E16.3  
NCBI Protein Information:histone H2B type 1-A
UniProt Protein Name:Histone H2B type 1-A
UniProt Synonym Protein Names:Histone H2B, testis; TSH2B.1; Testis-specific histone H2B
Protein Family:Histone
UniProt Gene Name:HIST1H2BA  
UniProt Entry Name:H2B1A_HUMAN

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