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Mono-methyl-HIST1H1D (K16) Antibody (PACO56588)

SKU:
PACO56588
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€349
Frequently bought together:

Description

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Mono-methyl-HIST1H1D (K16) Antibody (PACO56588)

The Mono-Methyl Hist1H1D (K16) Antibody (PAC056588) is a valuable tool for research involving Hist1H1D, a key protein involved in chromatin structure and gene regulation. This polyclonal antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for a variety of applications, including Western blotting.Hist1H1D is a histone protein that plays a crucial role in packaging DNA into chromatin and regulating gene expression. The mono-methylation of Hist1H1D at lysine 16 has been linked to various cellular processes, including transcriptional regulation and chromatin remodeling.

By targeting this specific modification, researchers can gain insight into the functional significance of Hist1H1D in different cell types and disease states.Overall, the Mono-Methyl Hist1H1D (K16) Antibody (PAC056588) provides a valuable tool for studying epigenetic modifications and their impact on gene expression and chromatin dynamics. Its high specificity and reactivity make it an essential resource for researchers interested in exploring the role of Hist1H1D in various biological processes, including cancer biology and developmental biology.

Antibody Name:Mono-methyl-HIST1H1D (K16) Antibody (PACO56588)
Antibody SKU:PACO56588
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Peptide sequence around site of Mono-methyl-Lys (16) derived from Human Histone H1.3
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescent analysis of Hela cells using PACO56588 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Synonyms:Histone H1.3 (Histone H1c) (Histone H1s-2), HIST1H1D, H1F3
UniProt Protein Function:H1D: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nuclear chromatin

Molecular Function:chromatin DNA binding

NCBI Summary:Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
UniProt Code:P16402
NCBI GenInfo Identifier:121925
NCBI Gene ID:3007
NCBI Accession:P16402.2
UniProt Secondary Accession:P16402,Q2M2I2, B2R751,
UniProt Related Accession:P16402
Molecular Weight:22,350 Da
NCBI Full Name:Histone H1.3
NCBI Synonym Full Names:histone cluster 1, H1d
NCBI Official Symbol:HIST1H1D  
NCBI Official Synonym Symbols:H1D; H1.3; H1F3; H1s-2  
NCBI Protein Information:histone H1.3
UniProt Protein Name:Histone H1.3
UniProt Synonym Protein Names:Histone H1c; Histone H1s-2
UniProt Gene Name:HIST1H1D  
UniProt Entry Name:H13_HUMAN
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