The MOGS Polyclonal Antibody (CAB12725) is a valuable tool for research involving the Mannosyl-oligosaccharide glucosidase (MOGS) protein, an enzyme involved in the processing of N-linked glycans. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to the MOGS protein, researchers can effectively detect and analyze its expression in various cell types, making it an ideal choice for studies in glycobiology, cell biology, and related fields.
MOGS is a key player in the glycosylation pathway, playing a critical role in the quality control of glycoprotein folding and maturation. Dysregulation of MOGS activity has been implicated in various human diseases, including congenital disorders of glycosylation and neurodegenerative conditions. By investigating the function of MOGS using this antibody, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
MOGS Rabbit Polyclonal Antibody
SKU:
CAB12725
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human MOGS (NP_006293.2).
Endoplasmic reticulum membrane, Single-pass type II membrane protein.
Calculated MW:
92kDa
Observed MW:
80kDa
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7841
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MOGS Rabbit pAb (CAB12725) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
