The MOGAT2 Polyclonal Antibody (PAC035962) is a valuable tool for researchers studying MOGAT2, an enzyme involved in triglyceride synthesis and lipid metabolism. This rabbit-raised antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the MOGAT2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in the fields of metabolism, lipid biology, and obesity research.
MOGAT2, also known as Monoacylglycerol O-Acyltransferase 2, is a key player in lipid biosynthesis pathways, particularly in the formation of triglycerides from monoacylglycerols. Understanding the role of MOGAT2 is crucial for unraveling the mechanisms underlying lipid metabolism and its implications for metabolic disorders like obesity and fatty liver disease. By targeting MOGAT2, researchers can gain insights into potential therapeutic strategies for addressing these health challenges.
Antibody Name:
MOGAT2 Antibody (PACO35962)
Antibody SKU:
PACO35962
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human 2-acylglycerol O-acyltransferase 2 protein (124-284AA)
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO35962 at dilution of 1:100.
Background:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acid, in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.
MOGAT2: Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Belongs to the diacylglycerol acyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.3.1.22; Acetyltransferase; Membrane protein, multi-pass; Membrane protein, integralCellular Component: membrane; endoplasmic reticulum; integral to membraneMolecular Function: transferase activity; 2-acylglycerol O-acyltransferase activity; acetyltransferase activity; transferase activity, transferring acyl groups; transferase activity, transferring groups other than amino-acyl groupsBiological Process: monoacylglycerol metabolic process; glycerol metabolic process; diacylglycerol biosynthetic process; triacylglycerol biosynthetic process; lipid metabolic process; intestinal absorption
