The MOGAT2 Polyclonal Antibody (PAC010544) is a valuable tool for researchers studying MOGAT2, an enzyme involved in triglyceride metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the MOGAT2 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for investigations in metabolic disorders and lipid metabolism research.MOGAT2, also known as monoacylglycerol O-acyltransferase 2, plays a crucial role in triglyceride synthesis by catalyzing the conversion of monoacylglycerol to diacylglycerol. Dysregulation of MOGAT2 has been implicated in various metabolic disorders, including obesity, non-alcoholic fatty liver disease, and insulin resistance.
Understanding the function of MOGAT2 is essential for developing targeted interventions to treat these conditions and improve metabolic health.Overall, the MOGAT2 Polyclonal Antibody offers researchers a reliable tool for investigating the role of MOGAT2 in metabolic pathways and its potential as a therapeutic target for metabolic disorders. Its high specificity and sensitivity make it a valuable asset for advancing our understanding of lipid metabolism and developing innovative treatments for metabolic diseases.
MOGAT2: Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Belongs to the diacylglycerol acyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 2.3.1.22; Acetyltransferase; Membrane protein, multi-pass; Membrane protein, integralCellular Component: membrane; endoplasmic reticulum; integral to membraneMolecular Function: transferase activity; 2-acylglycerol O-acyltransferase activity; acetyltransferase activity; transferase activity, transferring acyl groups; transferase activity, transferring groups other than amino-acyl groupsBiological Process: monoacylglycerol metabolic process; glycerol metabolic process; diacylglycerol biosynthetic process; triacylglycerol biosynthetic process; lipid metabolic process; intestinal absorption
