The MOG Polyclonal Antibody (CAB5353) is a essential tool for researchers studying myelin oligodendrocyte glycoprotein (MOG), a protein found in the central nervous system that is a target of autoimmune responses in multiple sclerosis. This antibody is generated in rabbits and has high reactivity with human samples, making it suitable for various applications including Western blotting.MOG is a key antigen in autoimmune demyelinating diseases, making this antibody valuable for investigating the role of MOG in the pathogenesis of multiple sclerosis and other related disorders. By specifically binding to MOG, this antibody allows for precise detection and analysis of MOG expression in different cell types, providing important insights into the mechanisms underlying these diseases.
The MOG Polyclonal Antibody is an essential tool for researchers in the fields of neurology, immunology, and autoimmune disorders. Its ability to target MOG with high specificity and sensitivity makes it an indispensable resource for studies aiming to understand the role of this protein in disease pathology and develop targeted therapies for autoimmune conditions affecting the central nervous system.
Cell membrane, Multi-pass membrane protein, Single-pass type I membrane protein.
Calculated MW:
28kDa
Observed MW:
28kDa
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
4340
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Myelin oligodendrocyte glycoprotein antibody (CAB5353) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
