MOCS2 Antibody (PACO28302)
- SKU:
- PACO28302
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MOCS2 Antibody (PACO28302)
The MOCS2 Antibody (PACO28302) is a highly specific polyclonal antibody designed for research involving MOCS2, a protein involved in the biosynthesis of molybdenum cofactor. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunofluorescence.MOCS2 plays a critical role in the activation of molybdoenzymes, which are essential for various metabolic processes in the body. Dysregulation of MOCS2 has been linked to disorders such as molybdenum cofactor deficiency, highlighting the importance of studying this protein in research.
By using the MOCS2 Antibody, researchers can effectively detect and analyze MOCS2 protein expression in cell lines and tissue samples, providing valuable insights into its function and relevance in metabolic pathways. This antibody is a valuable tool for studies in biochemistry, molecular biology, and metabolic disorders.
| Antibody Name: | MOCS2 Antibody (PACO28302) |
| Antibody SKU: | PACO28302 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Molybdopterin synthase catalytic subunit protein (1-188AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: MOCS2 antibody at 2µg/ml + Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 21 kDa Observed band size: 21 kDa . |
| Background: | Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. |
| Synonyms: | Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (MOCO1-B) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) (Molybdopterin-synthase large subunit) (MPT synthase large subunit), MOCS2, MCBPE MOCO1 |
| UniProt Protein Function: | MOCS2: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. Defects in MOCS2 are the cause of molybdenum cofactor deficiency type B (MOCOD type B). MOCOD type B is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Belongs to the MoaE family. MOCS2B subfamily. |
| UniProt Protein Details: | Protein type:Enzyme, misc.; EC 2.8.1.12 Chromosomal Location of Human Ortholog: 5q11 Cellular Component: cytoplasm; cytosol; molybdopterin synthase complex; nucleus Molecular Function:Mo-molybdopterin synthase activity Biological Process: Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process Disease: Molybdenum Cofactor Deficiency, Complementation Group B |
| NCBI Summary: | Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O96007 |
| NCBI GenInfo Identifier: | 20138899 |
| NCBI Gene ID: | 4338 |
| NCBI Accession: | O96007.1 |
| UniProt Secondary Accession: | O96007,Q6IAI3, |
| UniProt Related Accession: | O96007,O96033 |
| Molecular Weight: | 20,944 Da |
| NCBI Full Name: | Molybdopterin synthase catalytic subunit |
| NCBI Synonym Full Names: | molybdenum cofactor synthesis 2 |
| NCBI Official Symbol: | MOCS2Â Â |
| NCBI Official Synonym Symbols: | MPTS; MCBPE; MOCO1; MOCODBÂ Â |
| NCBI Protein Information: | molybdopterin synthase catalytic subunit; molybdopterin synthase sulfur carrier subunit |
| UniProt Protein Name: | Molybdopterin synthase catalytic subunit |
| UniProt Synonym Protein Names: | MOCO1-B; Molybdenum cofactor synthesis protein 2 large subunit |
| UniProt Gene Name: | MOCS2Â Â |
| UniProt Entry Name: | MOC2B_HUMAN |
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