MOB1B Antibody (PACO21883)
- SKU:
- PACO21883
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MOB1B Antibody (PACO21883)
The MOB1B Polyclonal Antibody (PACO21883) is a valuable tool for researchers studying MOB1B, a protein involved in various cellular processes including cell proliferation, cell cycle regulation, and tumor suppression. This antibody, produced in rabbits, exhibits high specificity for human samples and is suitable for use in Western blotting applications. By binding to MOB1B protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for research in cancer biology and cell signaling pathways.MOB1B is a key player in the Hippo signaling pathway, which is crucial for controlling organ size and tissue growth.
Dysregulation of this pathway has been linked to various types of cancer, making MOB1B a promising target for therapeutic interventions. By investigating the role of MOB1B in cell growth and proliferation, researchers can gain insights into potential treatments for cancer and other diseases associated with abnormal cell growth. The MOB1B Polyclonal Antibody is a valuable tool for unraveling the complexities of MOB1B function and its implications in disease development.
| Antibody Name: | MOB1B Antibody (PACO21883) |
| Antibody SKU: | PACO21883 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human MOL1A. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Devroe E., J. Biol. Chem. 279:24444-24451(2004). |
| Clonality: | Polyclonal |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 293 cells, COS-7 cells and HUVEC cells all treated with IFN (2500U/ml, 30mins), using MOL1A antibody. |
| Synonyms: | MATS2; MOB1; Mps One Binder kinase activator-like 1A; |
| UniProt Protein Function: | MOB1B: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. Binds STK38L. Interacts with LATS1 and LATS2. Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. Belongs to the MOB1/phocein family. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Activator Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:kinase activator activity; kinase binding; protein binding Biological Process: regulation of protein amino acid autophosphorylation |
| NCBI Summary: | The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q7L9L4 |
| NCBI GenInfo Identifier: | 56749324 |
| NCBI Gene ID: | 92597 |
| NCBI Accession: | Q7L9L4.3 |
| UniProt Secondary Accession: | Q7L9L4,Q8IY23, B2R8U6, B4DRY3, |
| UniProt Related Accession: | Q7L9L4 |
| Molecular Weight: | 25,499 Da |
| NCBI Full Name: | MOB kinase activator 1B |
| NCBI Synonym Full Names: | MOB kinase activator 1B |
| NCBI Official Symbol: | MOB1BÂ Â |
| NCBI Official Synonym Symbols: | MATS2; MOB4A; MOBKL1AÂ Â |
| NCBI Protein Information: | MOB kinase activator 1B |
| UniProt Protein Name: | MOB kinase activator 1B |
| UniProt Synonym Protein Names: | Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A |
| Protein Family: | MOB kinase activator |
| UniProt Gene Name: | MOB1BÂ Â |
| UniProt Entry Name: | MOB1B_HUMAN |
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