MOB1B Antibody (PACO01076)
- SKU:
- PACO01076
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- NHP - Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MOB1B Antibody (PACO01076)
The MOB1B Antibody (PACO01076) is a polyclonal antibody designed for research involving MOB1B, a protein that plays a key role in cell growth and division processes. The antibody, raised in rabbits, is highly specific and reactive with human samples, making it an ideal tool for studying MOB1B in various cell types.MOB1B is involved in the Hippo signaling pathway, which regulates organ size and tissue growth by controlling cell proliferation and apoptosis. Dysregulation of this pathway has been implicated in various diseases, including cancer and developmental disorders.
The MOB1B Antibody can be used in Western blot applications to detect and analyze MOB1B protein levels in cells, providing valuable insights into its function and potential therapeutic implications.Researchers studying cell growth, division, and signal transduction pathways will find the MOB1B Antibody to be a valuable tool in their investigations. By understanding the role of MOB1B in cellular processes, researchers can gain insights into the mechanisms underlying diseases and potentially identify new therapeutic targets for intervention.
| Antibody Name: | MOB1B Antibody |
| Antibody SKU: | PACO01076 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Monkey |
| Immunogen: | synthesized peptide derived from the Internal region of human Mob1A. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MOB1B; MOB4A; MOBKL1A; MOB kinase activator 1B; Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A |
| UniProt Protein Function: | MOB1B: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. Binds STK38L. Interacts with LATS1 and LATS2. Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. Belongs to the MOB1/phocein family. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Activator Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:kinase activator activity; kinase binding; protein binding Biological Process: regulation of protein amino acid autophosphorylation |
| NCBI Summary: | The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q7L9L4 |
| NCBI GenInfo Identifier: | 56749324 |
| NCBI Gene ID: | 92597 |
| NCBI Accession: | Q7L9L4.3 |
| UniProt Secondary Accession: | Q7L9L4,Q8IY23, B2R8U6, B4DRY3, |
| UniProt Related Accession: | Q7L9L4 |
| Molecular Weight: | 25,499 Da |
| NCBI Full Name: | MOB kinase activator 1B |
| NCBI Synonym Full Names: | MOB kinase activator 1B |
| NCBI Official Symbol: | MOB1BÂ Â |
| NCBI Official Synonym Symbols: | MATS2; MOB4A; MOBKL1AÂ Â |
| NCBI Protein Information: | MOB kinase activator 1B |
| UniProt Protein Name: | MOB kinase activator 1B |
| UniProt Synonym Protein Names: | Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A |
| Protein Family: | MOB kinase activator |
| UniProt Gene Name: | MOB1BÂ Â |
| UniProt Entry Name: | MOB1B_HUMAN |
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