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MOB1B Antibody (PACO01076)

SKU:
PACO01076
Product Type:
Antibody
Reactivity:
Human
Mouse
NHP - Monkey
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Antibody Name:MOB1B Antibody
Antibody SKU:PACO01076
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Monkey
Immunogen:synthesized peptide derived from the Internal region of human Mob1A.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MOB1B; MOB4A; MOBKL1A; MOB kinase activator 1B; Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A
UniProt Protein Function:MOB1B: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. Binds STK38L. Interacts with LATS1 and LATS2. Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver. Belongs to the MOB1/phocein family.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit; Activator

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:kinase activator activity; kinase binding; protein binding

Biological Process: regulation of protein amino acid autophosphorylation

NCBI Summary:The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:Q7L9L4
NCBI GenInfo Identifier:56749324
NCBI Gene ID:92597
NCBI Accession:Q7L9L4.3
UniProt Secondary Accession:Q7L9L4,Q8IY23, B2R8U6, B4DRY3,
UniProt Related Accession:Q7L9L4
Molecular Weight:25,499 Da
NCBI Full Name:MOB kinase activator 1B
NCBI Synonym Full Names:MOB kinase activator 1B
NCBI Official Symbol:MOB1B  
NCBI Official Synonym Symbols:MATS2; MOB4A; MOBKL1A  
NCBI Protein Information:MOB kinase activator 1B
UniProt Protein Name:MOB kinase activator 1B
UniProt Synonym Protein Names:Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A
Protein Family:MOB kinase activator
UniProt Gene Name:MOB1B  
UniProt Entry Name:MOB1B_HUMAN

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