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MOB1A Antibody (PACO20034)

SKU:
PACO20034
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • MOB1A Antibody PACO20034
  • MOB1A Antibody PACO20034
  • MOB1A Antibody PACO20034
€339
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Description

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MOB1A Antibody (PACO20034)

The MOB1A Polyclonal Antibody (PAC020034) is a valuable tool for studying MOB1A, a key regulator in cell division and growth pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.MOB1A is a critical component of the Hippo pathway, playing a crucial role in regulating cell proliferation, apoptosis, and tissue growth. Dysregulation of MOB1A has been linked to various diseases, including cancer and developmental disorders.

By targeting the MOB1A protein, this antibody allows for the detection and analysis of MOB1A expression in different cell types, providing researchers with insight into its function and potential therapeutic applications. Its utility in cell biology and oncology research makes it a valuable tool for investigating the role of MOB1A in disease progression and treatment development.

Antibody Name:MOB1A Antibody (PACO20034)
Antibody SKU:PACO20034
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthetic peptide of human MOB1A
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20034(MOB1A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Product ImageGel: 10%SDS-PAGE, Lysate: 40 µg, Lane 1-5: Hela cells, Jurkat cells, mouse liver tissue, K562 cells, A375 cells, Primary antibody: PACO20034(MOB1A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20034(MOB1A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:MOB1 was first identified in yeast as a protein that binds to Mps with essential roles in the completion of mitosis and the maintenance of ploidy. Its Drosophila and mammalian homologs, Mats and MOB1, respectively, are involved in the Hippo signaling tumor suppressor pathway, which plays a critical role in organ size regulation and which has been implicated in cancer development . There are two MOB1 proteins in humans, MOB1 α and MOB1 β , that are encoded by two different genes but which have greater than 95% amino acid, sequence identity.
Synonyms:MOB kinase activator 1A
UniProt Protein Function:MOB1A: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. Belongs to the MOB1/phocein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cytosol

Molecular Function:protein binding; metal ion binding

NCBI Summary:The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Code:Q9H8S9
NCBI GenInfo Identifier:56749356
NCBI Gene ID:55233
NCBI Accession:Q9H8S9.4
UniProt Related Accession:Q9H8S9
Molecular Weight:
NCBI Full Name:MOB kinase activator 1A
NCBI Synonym Full Names:MOB kinase activator 1A
NCBI Official Symbol:MOB1A  
NCBI Official Synonym Symbols:MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1B  
NCBI Protein Information:MOB kinase activator 1A
UniProt Protein Name:MOB kinase activator 1A
UniProt Synonym Protein Names:Mob1 alpha; Mob1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B
Protein Family:MOB kinase activator
UniProt Gene Name:MOB1A  
UniProt Entry Name:MOB1A_HUMAN
Antibodies
MOB1A Antibody (PACO10536)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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