MOB1A Antibody (PACO20034)
- SKU:
- PACO20034
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
MOB1A Antibody (PACO20034)
The MOB1A Polyclonal Antibody (PAC020034) is a valuable tool for studying MOB1A, a key regulator in cell division and growth pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.MOB1A is a critical component of the Hippo pathway, playing a crucial role in regulating cell proliferation, apoptosis, and tissue growth. Dysregulation of MOB1A has been linked to various diseases, including cancer and developmental disorders.
By targeting the MOB1A protein, this antibody allows for the detection and analysis of MOB1A expression in different cell types, providing researchers with insight into its function and potential therapeutic applications. Its utility in cell biology and oncology research makes it a valuable tool for investigating the role of MOB1A in disease progression and treatment development.
| Antibody Name: | MOB1A Antibody (PACO20034) |
| Antibody SKU: | PACO20034 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human MOB1A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20034(MOB1A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 10%SDS-PAGE, Lysate: 40 µg, Lane 1-5: Hela cells, Jurkat cells, mouse liver tissue, K562 cells, A375 cells, Primary antibody: PACO20034(MOB1A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20034(MOB1A Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | MOB1 was first identified in yeast as a protein that binds to Mps with essential roles in the completion of mitosis and the maintenance of ploidy. Its Drosophila and mammalian homologs, Mats and MOB1, respectively, are involved in the Hippo signaling tumor suppressor pathway, which plays a critical role in organ size regulation and which has been implicated in cancer development . There are two MOB1 proteins in humans, MOB1 α and MOB1 β , that are encoded by two different genes but which have greater than 95% amino acid, sequence identity. |
| Synonyms: | MOB kinase activator 1A |
| UniProt Protein Function: | MOB1A: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. Belongs to the MOB1/phocein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: cytosol Molecular Function:protein binding; metal ion binding |
| NCBI Summary: | The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9H8S9 |
| NCBI GenInfo Identifier: | 56749356 |
| NCBI Gene ID: | 55233 |
| NCBI Accession: | Q9H8S9.4 |
| UniProt Related Accession: | Q9H8S9 |
| Molecular Weight: | |
| NCBI Full Name: | MOB kinase activator 1A |
| NCBI Synonym Full Names: | MOB kinase activator 1A |
| NCBI Official Symbol: | MOB1AÂ Â |
| NCBI Official Synonym Symbols: | MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1BÂ Â |
| NCBI Protein Information: | MOB kinase activator 1A |
| UniProt Protein Name: | MOB kinase activator 1A |
| UniProt Synonym Protein Names: | Mob1 alpha; Mob1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B |
| Protein Family: | MOB kinase activator |
| UniProt Gene Name: | MOB1AÂ Â |
| UniProt Entry Name: | MOB1A_HUMAN |
| Antibodies |
| MOB1A Antibody (PACO10536) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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