The MNT Antibody (PACO06648) is a highly specific polyclonal antibody designed for research involving the MNT protein. MNT, a transcriptional repressor, is a key regulator of cell proliferation and differentiation, making it a crucial component in cancer biology and developmental biology research. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as immunofluorescence and immunohistochemistry. By binding to the MNT protein, the antibody facilitates the detection and analysis of MNT expression in various cell types, providing researchers with valuable insights into its role in cellular processes.
With its ability to target MNT, this antibody is ideal for studies in cancer research, where MNT is known to play a significant role in tumor growth and progression. Additionally, the MNT Antibody is also useful for investigating the molecular mechanisms underlying developmental disorders and cell differentiation.Overall, the MNT Antibody (PACO06648) is a versatile tool for researchers looking to further their understanding of MNT function in both normal and disease states, offering valuable insights that can advance scientific knowledge and potentially lead to the development of new therapeutic strategies.
Antibody Name:
MNT Antibody (PACO06648)
Antibody SKU:
PACO06648
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human MNT.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of Jurkat cells using MNT Polyclonal Antibody.
Western Blot analysis of A549 cells using MNT Polyclonal Antibody.
Synonyms:
MNT; BHLHD3; ROX; Max-binding protein MNT; Class D basic helix-loop-helix protein 3; bHLHd3; Myc antagonist MNT; Protein ROX
UniProt Protein Function:
MNT: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 17p13.3Cellular Component: nucleoplasm; nucleusMolecular Function: protein dimerization activity; transcription coactivator activity; chromatin binding; transcription factor activity; transcription corepressor activityBiological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; regulation of cell cycle; multicellular organismal development; cell aging; negative regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]
max-binding protein MNT; myc antagonist MNT; MAX binding protein; Max-interacting protein; MNT, MAX dimerization protein; class D basic helix-loop-helix protein 3
UniProt Protein Name:
Max-binding protein MNT
UniProt Synonym Protein Names:
Class D basic helix-loop-helix protein 3; bHLHd3; Myc antagonist MNT; Protein ROX
