MNDA Antibody (PACO51714)
- SKU:
- PACO51714
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MNDA Antibody (PACO51714)
The MNDA Polyclonal Antibody (PAC051714) is a powerful tool for researchers studying MNDA, a key player in the immune response. MNDA, also known as myeloid cell nuclear differentiation antigen, is involved in the regulation of gene expression in myeloid cells and has been implicated in various disease processes.This antibody is produced in rabbits and is highly specific for detecting MNDA in human samples. It has been validated for use in Western blot applications, allowing researchers to analyze MNDA expression levels in different cell types and tissues.
By targeting MNDA, researchers can gain valuable insights into the role of this protein in diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of MNDA could lead to the development of novel therapies that target this molecule for the treatment of these diseases.Overall, the MNDA Polyclonal Antibody is a valuable tool for researchers interested in studying the role of MNDA in the immune system and its potential implications for disease pathogenesis.
| Antibody Name: | MNDA Antibody (PACO51714) |
| Antibody SKU: | PACO51714 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Myeloid cell nuclear differentiation antigen protein (84-233AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse heart tissue, Mouse kidney tissue. All lanes: MNDA antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46 kDa. Observed band size: 46 kDa.. |
 | Immunofluorescent analysis of MCF-7 cells using PACO51714 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human skin tissue using PACO51714 at dilution of 1:100. |
| Background: | May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1. |
| Synonyms: | Myeloid cell nuclear differentiation antigen, MNDA |
| UniProt Protein Function: | May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1. |
| NCBI Summary: | The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41218 |
| NCBI GenInfo Identifier: | 730038 |
| NCBI Gene ID: | 4332 |
| NCBI Accession: | P41218.1 |
| UniProt Related Accession: | P41218 |
| Molecular Weight: | 407 |
| NCBI Full Name: | Myeloid cell nuclear differentiation antigen |
| NCBI Synonym Full Names: | myeloid cell nuclear differentiation antigen |
| NCBI Official Symbol: | MNDAÂ Â |
| NCBI Official Synonym Symbols: | PYHIN3Â Â |
| NCBI Protein Information: | myeloid cell nuclear differentiation antigen |
| UniProt Protein Name: | Myeloid cell nuclear differentiation antigen |
| Protein Family: | Myeloid cell nuclear differentiation antigen |
| UniProt Gene Name: | MNDAÂ Â |
| UniProt Entry Name: | MNDA_HUMAN |
| Antibodies | ELISA Kits |
| MNDA Antibody (PACO02908) | Human MNDA / Myeloid cell nuclear differentiation ELISA Kit |
| MNDA Antibody (PACO10534) | Human Myeloid cell nuclear differentiation antigen (MNDA) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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