MNDA Antibody (PACO22433)
- SKU:
- PACO22433
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
MNDA Antibody (PACO22433)
The MNDA Monoclonal Antibody (PACO22433) is a valuable tool for researchers studying the MNDA protein, which is involved in immune regulation and host defense against pathogens. This antibody is produced using hybridoma technology, ensuring high specificity and sensitivity in detecting MNDA in human samples.MNDA is a nuclear protein that plays a crucial role in regulating gene expression and immune response pathways. It is known to be involved in the differentiation and activation of myeloid cells, as well as in the defense against viral infections. Research into MNDA can provide insights into immune cell function and the development of immune-based therapies for infectious diseases and autoimmune disorders.
The MNDA Monoclonal Antibody is suitable for various applications, including Western blotting, immunofluorescence, and immunohistochemistry. Its specificity for MNDA makes it an invaluable tool for researchers studying the molecular mechanisms underlying immune response and host defense. Order now and advance your research in immunology and infectious diseases with the MNDA Monoclonal Antibody (PACO22433).
| Antibody Name: | MNDA Antibody (PACO22433) |
| Antibody SKU: | PACO22433 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from C-terminal of human MNDA. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from LOVO cells, using MNDA antibody. |
| Background: | The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. |
| Synonyms: | myeloid cell nuclear differentiation antigen; PYHIN3; |
| UniProt Protein Function: | May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1. |
| NCBI Summary: | The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41218 |
| NCBI GenInfo Identifier: | 730038 |
| NCBI Gene ID: | 4332 |
| NCBI Accession: | P41218.1 |
| UniProt Related Accession: | P41218 |
| Molecular Weight: | 407 |
| NCBI Full Name: | Myeloid cell nuclear differentiation antigen |
| NCBI Synonym Full Names: | myeloid cell nuclear differentiation antigen |
| NCBI Official Symbol: | MNDAÂ Â |
| NCBI Official Synonym Symbols: | PYHIN3Â Â |
| NCBI Protein Information: | myeloid cell nuclear differentiation antigen |
| UniProt Protein Name: | Myeloid cell nuclear differentiation antigen |
| Protein Family: | Myeloid cell nuclear differentiation antigen |
| UniProt Gene Name: | MNDAÂ Â |
| UniProt Entry Name: | MNDA_HUMAN |
| Antibodies | ELISA Kits |
| MNDA Antibody (PACO02908) | Human MNDA / Myeloid cell nuclear differentiation ELISA Kit |
| MNDA Antibody (PACO10534) | Human Myeloid cell nuclear differentiation antigen (MNDA) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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