Mnda Antibody (PACO10534) is a high-quality polyclonal antibody designed for research involving the MNDA protein, which plays a crucial role in immune regulation and inflammatory responses. This antibody, produced through rigorous testing and validation processes, is raised in rabbits and is highly reactive with human samples, making it an excellent tool for Western blot applications.MNDA, also known as myeloid cell nuclear differentiation antigen, is involved in the regulation of immune responses and is linked to various diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
Understanding the function and expression of MNDA is essential for advancing research in immunology and disease pathology.The MNDA Antibody (PACO10534) binds specifically to the MNDA protein, enabling precise detection and analysis in a variety of cell types. Its versatility makes it an ideal choice for researchers studying immune regulation, inflammation, and disease mechanisms. By utilizing this antibody, scientists can gain valuable insights into the role of MNDA in health and disease, potentially leading to the development of novel therapeutic strategies.
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
NCBI Summary:
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
