The MNDA Antibody (PAC02908) is a high-quality research tool designed for the detection and analysis of the myeloid cell nuclear differentiation antigen (MNDA). This polyclonal antibody, produced in rabbits, targets MNDA, a nuclear protein involved in cell differentiation and immune responses.MNDA is known to play a role in the regulation of gene expression and the immune response, making it a key player in the development and function of myeloid cells. The MNDA Antibody (PAC02908) is validated for use in various applications, including Western blotting, immunofluorescence, and immunohistochemistry.Researchers in the fields of immunology, oncology, and cell biology can utilize this antibody to study the function and expression of MNDA in different cell types and tissues.
By understanding the role of MNDA in immune regulation and cell differentiation, scientists can gain valuable insights into various diseases and develop potential therapeutic strategies targeting MNDA in conditions such as cancer and autoimmune disorders.Overall, the MNDA Antibody (PAC02908) is a valuable tool for researchers looking to explore the intricate mechanisms of immune regulation and cell differentiation, with the potential for advancing our understanding of disease pathogenesis and therapeutic development.
Antibody Name:
MNDA Antibody
Antibody SKU:
PACO02908
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human MNDA.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
NCBI Summary:
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
